Neuroinflammation is involved in various neurological diseases. Activated microglia\nsecrete many pro-inflammatory factors and induce neuronal cell death. Thus, the inhibition of\nexcessive proinflammatory activity of microglia leads to a therapeutic effect that alleviates the\nprogression of neuronal degeneration. In this study, we investigated the effect of Croton tiglium (C.\ntiglium) Linn. extract (CTE) on the production of pro- and anti-inflammatory mediators in microglia\nand astrocytes via RT-PCR, Western blot, and nitric oxide assay. Neurotoxicity was measured by\ncell viability assay and GFP image analysis. Phagocytosis of microglia was measured using\nfluorescent zymosan particles. CTE significantly inhibited the production of neurotoxic\ninflammatory factors, including nitric oxide and tumor necrosis factor......................
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